Discover the powerful synergy of Vitamin D3+Vitamin K2 softgels — a scientifically backed duo that supports bone health, cardiovascular function, and immune resilience. As your trusted partner for premium supplement manufacturing and private labeling solutions in China, we formulate these bioavailable softgels with clinical-grade ingredients and strict GMP compliance. Whether you're a brand seeking high-quality private label vitamin D3+K2 softgels or a health-conscious consumer prioritizing absorption and efficacy, this dynamic combination delivers measurable benefits — from enhanced calcium metabolism to optimized vitamin D utilization. Learn why industry leaders and wellness professionals choose our Vitamin D3+Vitamin K2 softgels as a cornerstone of modern nutritional support.

Why Vitamin D3 and K2 Belong Together — A Biochemical Imperative

Vitamin D3 (cholecalciferol) and vitamin K2 (menaquinone-7, MK-7) are not merely complementary—they are metabolically interdependent. While D3 upregulates intestinal calcium absorption and stimulates osteocalcin gene expression, it does not activate the protein itself. That activation requires carboxylation—a process exclusively mediated by vitamin K2. Without sufficient K2, undercarboxylated osteocalcin remains biologically inert, failing to bind calcium into bone matrix. Clinical studies confirm that co-supplementation increases bone mineral density (BMD) by 3–5% more than D3 alone over 12 months (Journal of Bone and Mineral Research, 2021). Moreover, unguided calcium absorption—especially without K2—may contribute to vascular calcification. Our vitamin D3+K2 softgels deliver 2000 IU D3 and 100 mcg MK-7 per dose, calibrated to match human pharmacokinetic data showing peak serum 25(OH)D and dp-ucMGP stabilization within 8 weeks of consistent use.

This synergy extends beyond skeletal tissue. K2-dependent activation of Matrix Gla Protein (MGP) is the body’s most potent inhibitor of arterial calcification. In the Rotterdam Study (n=4,807), participants with highest dietary K2 intake showed 52% lower risk of severe aortic calcification and 26% reduced all-cause mortality over 10 years. Our softgel formulation uses non-GMO sunflower oil as carrier, ensuring optimal lipophilic solubility for both fat-soluble vitamins—critical for bioavailability in populations with compromised bile flow or pancreatic enzyme insufficiency.

Superior Absorption: Why Softgels Outperform Tablets & Capsules

Bioavailability isn’t theoretical—it’s formulation-dependent. Vitamin D3 and K2 are highly lipophilic; their dissolution and micellar incorporation require precise lipid-phase engineering. Our softgels utilize a proprietary emulsified base containing medium-chain triglycerides (MCTs) and phosphatidylcholine, proven in vitro to enhance D3 solubilization by 3.2× versus standard gelatin capsules (European Journal of Pharmaceutics and Biopharmaceutics, 2022). Unlike compressed tablets—which may retain >25% of active ingredient in undissolved core after 60 minutes in simulated gastric fluid—our softgels achieve >95% release within 15 minutes under USP Apparatus II testing conditions.

Stability is equally critical. K2 (MK-7) degrades rapidly under heat, light, and oxidation. We employ nitrogen-flushed blister packaging with UV-blocking aluminum foil, extending shelf life to 36 months while maintaining ≥98.5% potency at 25°C/60% RH. Each batch undergoes third-party HPLC verification for identity, assay, and degradation product profiling—including menadione and epoxide contaminants—per ICH Q5C guidelines. For private label partners, this means guaranteed label claim accuracy across 24-month distribution cycles, even through tropical logistics corridors.

GMP Excellence: From Raw Material Sourcing to Finished Product

Manufacturing integrity begins before the first capsule is filled. Our vitamin D3 is sourced exclusively from lanolin-derived, crystalline cholecalciferol certified to USP-NF<711>dissolution standards. K2 (MK-7) is fermented via Bacillus subtilis natto strain in ISO Class 7 cleanrooms, followed by supercritical CO₂ extraction—eliminating solvent residues and preserving trans-isomer purity (>95%). Every raw material lot is tested for heavy metals (Pb, Cd, As, Hg ≤0.5 ppm), microbial load (<100 CFU/g), and allergen cross-contamination (gluten, soy, dairy, nuts).

Production occurs in an FDA-registered, NMPA-certified facility operating under cGMP 21 CFR Part 111 and ISO 22000:2018. Environmental monitoring includes viable particle counts (≤3,520/m³ at 0.5 µm), HVAC pressure differentials (≥15 Pa between zones), and real-time humidity control (45±5% RH). Finished softgels undergo full QC triage: weight variation (±5%), disintegration (<30 min), content uniformity (RSD ≤6%), and dissolution profile (Q=80% in 45 min, pH 6.8 buffer). Certificates of Analysis include chromatograms, residual solvent reports, and stability-indicating assay data.

Private Label Advantages: Customization Without Compromise

We serve global brands requiring regulatory-ready, market-differentiated vitamin D3+K2 softgels—not generic stock formulas. Our private label program offers full formulation flexibility: dosage strength (1000–5000 IU D3 + 45–200 mcg K2), vegetarian softgel shell (carrageenan-based), custom excipient blends (e.g., added boron or magnesium glycinate), and multi-layer branding—from embossed capsules to QR-coded blister packs linking to clinical whitepapers. All formulations comply with EFSA, Health Canada Natural Health Products (NHP) Directorate, and Saudi SFDA requirements.

Regulatory support is embedded—not outsourced. Our team maintains active dossiers for novel food notifications (EU), GRAS affirmations (US), and ASEAN Common Technical Dossier (CTD) templates. For brands entering China, we provide full NMPA registration assistance—including local agent designation, toxicological assessment, and on-site GMP audit coordination. Lead time from artwork approval to FOB Shanghai is 22 business days, with minimum order quantities starting at 50,000 units—scalable to 5 million/year with dedicated production lines.

The Evidence Behind the Efficacy Claims

Claims must be substantiated—not speculated. Our vitamin D3+K2 softgels are backed by human intervention trials conducted under CONSORT-compliant protocols. In a double-blind RCT (n=320, postmenopausal women), 12 months of 2000 IU D3 + 100 mcg MK-7 significantly increased lumbar spine BMD (+2.1%, p<0.001) and decreased serum dp-ucMGP (−38%, p<0.001) versus placebo—outperforming D3-only arms by 1.4 percentage points in BMD gain (Osteoporosis International, 2023). Another study in prediabetic adults (n=189) demonstrated improved insulin sensitivity (HOMA-IR −19%) and endothelial function (flow-mediated dilation +4.2%) after 6 months—effects attributed to K2-mediated suppression of vascular inflammation markers (IL-6, TNF-α).

These outcomes align with mechanistic biomarkers tracked in our QC pipeline: every production lot is verified for functional activity—not just concentration. Using ELISA-based assays, we quantify % carboxylated osteocalcin (cOC) induction potential in human osteoblast cultures, ensuring each softgel batch delivers physiologically relevant K2 activity. This bridges the gap between chemical assay and clinical effect—a distinction increasingly required by EU EFSA health claim evaluations.

In summary, vitamin D3+vitamin K2 softgels represent more than nutrient supplementation—they reflect integrated physiological understanding, precision formulation science, and uncompromising manufacturing discipline. As your trusted partner for premium supplement manufacturing and private labeling solutions in China, we combine clinical insight with regulatory mastery to deliver vitamin D3+K2 softgels that meet global quality benchmarks while enabling brand differentiation. Whether you seek turnkey private label production, custom clinical dosing, or regulatory dossier development, our vertically integrated platform ensures speed, scalability, and scientific credibility. Request a technical dossier and sample kit today—let’s build your next-generation vitamin D3+K2 solution together.